The drug, Journavx, from Vertex Pharmaceuticals, reduced pain after surgery in clinical trials. Experts hope it can lead to fewer opioid prescriptions.
  • Nosavingthrow@lemmy.world
    17·
    3 months ago

    10000% there are side effects that they know about and will hide. I’m willing to place my honor as a gentleman on the line.

    • Buddahriffic@lemmy.world
      2·
      3 months ago

      Imo all safety studies should be duplicated, with one run by someone that wants the study to give a safe and effective conclusion and another run by someone who wants the study to give a dangerous or ineffective conclusion. Both studies monitored by neutral parties that are rewarded based on how long the studies stand up for. And no NDAs (or at least no NDAs that don’t expire once the product hits the market) so that all three can be vocal about any issues they had with how the others wanted things run.

      And criminal charges for any kind of corruption.

  • Jonathan@lemmy.world
    11·
    3 months ago

    I have chronic pain and I’m all for innovation in the realm of pain management, but I personally won’t even think about taking that drug for many, many years. Fucking with sodium channels sounds super dangerous. There are so many variables they just could not have tested or even guessed at. It also doesn’t help that if there’s an adverse reaction to be had, I’m gonna have it.

    • Xanthobilly@lemmy.world
      7·
      3 months ago

      It targets a sodium channel that only exists in pain neurons, called NAV1.8, or SCN10A. It’s not found elsewhere in the body. The whole reason this research is exciting is because it would be so specific it wouldn’t have the side effects seen with opioids or any anesthetic for that matter—central depression, which is what causes your breathing to stop.

      • Jonathan@lemmy.world
        2·
        3 months ago

        It is very interesting and amazing stuff, no doubt about that. The future of medicine is only going to get more amazing, but I suppose I just really have very little confidence in that space because of a lack of understanding in oddball humans like myself who have somewhat bizarre physiology. For the vast majority of people, I think having a pain medication that doesn’t also slowly kill you is obviously a net positive.