obviously
anybody who believes pharma costs are justified by materials is… well, let’s just call them uninformed. It’s not justified by R&D costs or production issues. It’s justified by the stock market, by the CEO having a race with other pharma CEOs for the biggest bonus, and by no other thing.
I work in med device, close to pharma, but a bit different. There is a lot of overhead. Beyond all the validations required for startup of each line, there is quite a lot of Sustaining work.
I’m not trying to defend this price, or the gouging that pharma does regularly. But I don’t think the $5 price includes all the overhead of the QMS.
It’s like taking the price of the ingredients for a pizza and saying it’s what it should cost.
Well if the materials to make a pizza was 5 dollars and it was being sold at 1,000 dollars, saying “oh thats just necessary overhead” would lead me to wonder why the hell that level of inefficiency was tolerated.
Because each new type of pizza is made of brand-new ingredients, not just standard wheat flour, tomatoes, cheese, spices, etc. And they’re baked anew and taste-tested to make sure they’re not disgusting, or worse, have toxic effects.
why the hell that level of inefficiency was tolerated.
Patents, e.g. legal monopolies.
Maybe fines and penalties for undercutting someone who holds a patent should be scrapped for nonprofit manufacturers of generics.
Maybe profit should come second to the betterment of humanity.
I’m sure there are some costs associated with developing drugs, and I’m sure it’s not cheap.
The problem still stands, though, and the solution is capping executive pay in public companies.
It’s justified by asking “how much money can we suck out of the people it helps?”
Normally you can think of these prices as the reward to taking a risk. The chance of developing a drug and bringing it to market is usually small, and the reward should accordingly be high. However, in the particular case of Ozempic, the company attempted to develop a diabetes drug, and accidentally found that the drug works against obesity. That means that the reward in this case outweighs the risk by an obscene amount.
Well you see… there’s the yacht, the yacht they have to land the helicopter, and the smallish yacht they use to go into port because berths at dock are hard to come by.
Oh and the. There’s the helicopter, the pilots, the mansion in every state. Except, uh, the ones that tax rich people.
It’s all part of the cost…
You forgot the biggest expense; the billions of dollars in stock buybacks.
CAD$650/month in Canada. I’ve lost 36 Kg (80 lbs) and I’m still losing weight. My blood work shows no signs of diabetes, my cardiac indicators are also excellent, but my hemoglobin is low because I don’t eat beef anymore (not because of the Ozempic, I haven’t been able to digest it for about six years.) I’m taking an iron supplement to build it back up.
Ozempic sucks until you stop fighting it. After that it’s an easy ride.
I’m wearing an XL t-shirt and large sweat pants today down from 3XL in both eight months ago.
Any side effects?
It acts by slowing down the emptying of your stomach. That means that whatever you eat stays in your stomach for many hours. If you eat too much at night or something that is acidy or spicy it causes terrible heart burn and reflux/regurgitation. I take an omeprazole with sodium bicarbonate at bedtime to relieve the acid.
I eat a granola bar or a couple of eggs for breakfast then a small bowl of whatever is on offer for dinner and that’s it. My stomach is never empty. Sometimes, if I want to have something spicy or acidy I will have it for breakfast. I’ve had a fajita for breakfast and I once had chicken parm for breakfast. Then I eat something easy for dinner.
The most upsetting side effect was the fact that I went from a daily bathroom guy to every three or four days. I was eating so much less and my body was making such good use of what I ate that I just didn’t produce much. It can cause constipation but you need to avoid taking laxatives because you can become dependant. Just drink lots of water, eat lots of fiber, and walk a lot and you will be fine.
If you fight it it’s going to make you miserable. If you lean in you will lose a lot of weight fast. I’ve lost so much weight so quickly that my body freaks me out a bit. When I’m sitting on the edge of the bed and look down at my legs I don’t recognize them. I told someone a few weeks ago that I just wanted a little candy because I’m fat and she said, “No you’re not.”
On the plus side I mentioned to my doctor that I was getting shorter (in in my late 50s and went from 5’ 10 1/2" to 5’ 9 1/2" and he asked, “Your penis?” I said, “No, that’s getting longer!” He laughed and said, “It was hiding.” I’ve actually gained an inch and a half of useable penis. (That’s a happy side effect.)
Ozempic sucks until you stop fighting it. After that it’s an easy ride.
Are there plateaus like with other weight loss?
I’m not eating any solid food due to a medical issue (long story) and I have lost 80 pounds as well. My weight can drop very quickly sometimes, as much as a pound every few days. Other times, like recently, it takes a long time to go down. It’s taken me a good two months to go from 190 to 180, whereas I was 260 at the start of January 2023.
If not eating enough period causes plateaus, I would think Ozempic would as well.
I plateaued in the low 220s for a month or so then the weight fell off me to the low 200s. I’m creeping down now at about half a pound per week. My ultimate goal was to get to 200 lbs but I’m now thinking that I may go to 190 lbs since the weight is continuing to come off. I don’t want to go lower than that. I don’t want to be a thin person. I just want to be less fat.
article doesnt present any pressure they are facing. also
Drug production costs are often shrouded in secrecy with little clarity on how they relate to prices, if at all.
Prices are never about cost, its what people are willing to pay. Which gets brutally exploited by pharmaceutical industry.
Double pop! First time I’ve seen a privacy popup on top of a privacy popup. The top one you can only accept.
deleted by creator
Extra privacy wow!
Ah I see they are going the Roku route.
Meanwhile volvo assigns the patent for the 3-point seatbelt to the public domain because it will save countless lives.
A Swedish company not being evil? What are they, the opposite of America?
Novo Nordisk is a Danish company, not American.
We were talking about Volvo.
Right. But based on context clues, it’s implied that the full meaning of the post was “Volvo did something for the public good, therefor Volvo is good. Volvo is a Swedish company. Swedish companies are good. Sweden is in Europe. European countries are good. American countries are bad. Novo Nordisk did something bad. It must be an American company.”
Admittedly, my mistake was not being more clear about the point of my response which is that geography is irrelevant - capitalism and all companies are evil (or at best, amoral).
That was in no way what I was saying, which about U.S. companies pretty much never doing the right thing and European companies actually doing that sometimes.
well you know the old adage, the bigger the margin, the better the rape
There’s a lot of mistrust with drug makers at the moment, for good reason and this is a great article on the breakdown of costs. They do have a point about recouping the cost of R&D but maybe they should be more transparent about how long it’ll take them to do so. MBAs are very good at pulling levers to make money, they just don’t think about the human element, which is the most important lever.
Two points about R&D costs:
First, they aren’t just trying to make up what they spent on this treatment, but others that failed during research/trials. There’s a lot of them the general public will never hear about, and pharmas generally don’t like to bring attention to their failures. Part of that is many shareholders are morons who don’t understand how science works.
Second, the costs can get fuzzier for larger companies who in-house much of the R&D process, since the costs get shared among many programs. Properly attributing spend in that case can be a serious challenge.
All that said, they’ve clearly seen an opportunity to rake it in with this trendy drug and are charging way more than they need to.
So why didn’t anyone else start manufacturing it for $5 about 15 years ago then?
Patents most likely.
Interestingly its always libertarian types defending patents; rather than being against it for being government intervention.
In either case patents and copyright need reform for today’s economy.
It was only approved very recently. Manufacturing it years ago would have been a waste, because you wouldn’t have been able to sell it.
That’s the thing.
Developing drugs, from a theoritical cure for something to an actual approved drug, normally takes years and a lot of drugs gets scrapped during this process. You don’t just have to prove that the drug is not causing more harm, your also have to prove how effective it is. There a lot of full time employee people involved in everything from developing the actual chemical to executing clinical tests.
I’m not in any way defending the way “big pharma” acts today, but all of this is more complicated than a guy suddenly saying “I’m going to create a drug that cures cancer” and then just does it in 2 years.
So out of the 10 drugs you pour a couple of millions into the development of, just 1 or 2 might make it through and get approved. If you’re lucky. So even if it’s just costs $5 manufacture that specific drug, the company still have to cover the losses from the other 8-9 that never made it.
Once again, I’m not defending all pharmaceutical companies. I’m just saying that the manufacturing cost of a drug that is approved is far from the actual cost.
If you understand all that, then why did you ask why they didn’t manufacture it?
Guy looks like Bill Gates without hair.
$1500. That’s how much eight weeks of ozempic costs for me if I had to pay out of pocket.
Guys our government is broken.
I’m diabetic, and also have a few mental health issues. The doc took me off Ozempic, citing it’s side affects of messing with mental health.
Sorry to hear it. What sort of side effects were there?
Doc said risks were reported of adversely affecting PTSD, depression, and suicidal thoughts.
Oh wow. Yeah, definitely a good idea to stop taking it. I’m glad you’re still with us and I hope you’ve found a good solution!
Thanks, I’m doing pretty well. But I don’t need a drug with those side effects. I mention this primarily because these side effects appear to be largely unreported, while the drug is being widely marketed for weight loss. People should be aware of the risks.
